Study of IL4Rα and IL13Rα1 Expression in Gallbladder Cancer

Recently, IL4Rα, IL13Rα1, and constituents of type II IL4 receptors are involved in the progression human cancers through activation JAK2 pathway. However, studies on IL4Rα IL13Rα1 gallbladder (GB) have been limited. To investigate expression 122 GB carcinomas effect inhibition SNU308 cancer cells. In carcinomas, were evaluated with immunohistochemical staining tissue microarray sections. Immunohistochemical was significantly associated carcinoma tissue. univariate analysis, nuclear cytoplasmic overall shorter survival relapse-free survival. Multivariate analysis revealed as an independent poor prognostic indicator cells, knock-down or decreased phosphorylated JAK2. The treatment AZD1480, a inhibitor, inhibited proliferation increased apoptosis western blot, AZD1480 cleaved PARP1, caspase-3, Bax, Bim, p21, p27, FOXO3, but Bcl2 pJAK2 This study showed that especially potential carcinomas. Furthermore, suppression IL4R pathway inhibitor might be effective therapeutic approach to